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|Section2= |Section3= }} Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone. Additionally, NKB is associated with pregnancy in females and maturation in young adults. Reproductive function is highly dependent on levels of both neurokinin B and also the G-protein coupled receptor ligand kisspeptin. The first NKB studies done attempted to resolve why high levels of the peptide may be implicated in pre-eclampsia during pregnancy. NKB, kisspeptin, and dynorphin together are found in the arcuate nucleus (ARC) known as the KNDy subpopulation. This subpopulation is targeted by a large number of steroid hormones and works to form a network that feeds back to GnRH pulse generator. ==Synthesis== Neurokinin B is found in humans as a ten-peptide chain (decapeptide) attached to a terminal amide group. The peptide formula is H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2. Neurokinin b (NKB), is encoded by the TAC3 gene in humans and Tac2 in rodent species. Neurokinin b is expressed along with the peptides kisspeptin and dynorphin A in the neuronal cells of the arcuate nucleus.〔 Five exon segments in the TAC3 gene encode for the NKB precursor known as preprotachykinin B. Preprotachykinin B is then proteolytically cleaved into the pro-peptide proneurokinin B. A second proteolytic cleavage of proneurokinin B produces the final product neurokinin B.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Neurokinin B」の詳細全文を読む スポンサード リンク
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